Assessment of Spring Leaf Extract of <i>Artemisia aucheri</i> Effects on <i>Leishmania tropica/infantum</i>

Background: Leishmania infection is a serious worldwide health concern that caused by various types of parasite genus. Current therapies for this disease, including pentavalent antimonial complexes, are not safe and do have enough efficacy. The Artemisia aucheri spring leaf extract has been reported to antimicrobial effects on variety pathogens. Objective: This study aimed find how A. affects tropica infantum. Materials Methods: After culturing macrophages L. infantum in enriched the Roswell Park Memorial Institute (RPMI) 1640 culture medium with 10% fetal bovine serum (FBS), impacts different dosages extracts tropica, as well promastigotes were evaluated vitro. In addition, 2, 5-diphenyltetrazolium bromide was used assess cytotoxicity parasites macrophages. Eventually, flow cytometry annexin staining performed evaluate potential apoptosis induction tropica/infantum. Results: test results showed amount 22.28% parasites. inhibitory concentration 15.17 9.13 infantum, respectively. Conclusion: Overall, revealed good in-vitro anti-leishmania effect promastigotes.